Short term Antimycotic and Toxicity Profile of ethanol extract of Solatnum eriatnthum on Candida albicans

Abstract

• Introduction: Solatnum eriatnthumis medicinal plant used by folklore all over the world. There is no studies conducted on the toxicological effect of the plant. The present study aims to evaluate the toxicological effect of methanol extract of the leaf of the plant.

  Results: The fruit pulp extracts were effective against the organism at 475 and 485 mg/ml in the aqueous and ethanolic extract respectively. The same concentration served as the Minimum Inhibi-tory and Minimum Fungicidal Concentration (MIC and MCC) in both extracts. The extracts were also subjected to qualitative and quantitative phyto-chemical analysis. Alkaloids, tannins and reducing sugars were found in the ethanol extract while in the aqueous extract glycosides, saponins and re-ducing sugars were discovered to be present.
  Conclusions: The study indicated that aqueous and ethanolic extracts of the fruit pulp of T. indica can be a potential source of antimycotic agent to com-bat the challenge of the emergence of drug-resistance in Candida albicans and the need to produce more effective antimicrobial agents.